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๐Ÿ”ฌ PathophysiologyAdvanced 18 min read

Chronic Kidney Disease: Pathophysiology

CKD staging, uremic syndrome manifestations, complications across body systems, renal replacement therapy, and nursing management.

CKDchronic kidney diseasedialysisGFRuremia

CKD Definition & Staging

CKD: GFR <60 mL/min/1.73mยฒ for >3 months OR evidence of kidney damage. KDIGO Staging: Stage 1 (G1): GFR โ‰ฅ90; Stage 2 (G2): 60โ€“89; Stage 3a: 45โ€“59; Stage 3b: 30โ€“44; Stage 4: 15โ€“29; Stage 5: <15 or dialysis (ESRD). Common causes: Diabetic nephropathy (#1), Hypertension (#2).

Systemic Complications

Cardiovascular: hypertension, LVH, accelerated atherosclerosis โ€” leading cause of death in CKD. Hematological: normocytic anemia (decreased EPO). Metabolic: hyperkalemia, metabolic acidosis, hyperphosphatemia, hypocalcemia. Neurological: uremic encephalopathy, peripheral neuropathy.

Renal Replacement Therapy

Hemodialysis (HD): blood filtered through artificial kidney 3ร—/week. Requires AV fistula/graft (never BP or IV in that arm). Peritoneal dialysis (PD): home-based; uses peritoneum as membrane. Kidney transplant: best long-term option; immunosuppression required lifelong.

Nursing Management

Fluid restriction. Dietary: low potassium, low phosphorus, low sodium. Medications: ESA for anemia, phosphate binders (with meals), Vitamin D. Monitor access site (fistula: palpate thrill, auscultate bruit). AV fistula protection: no BP, IV, or tight clothing.

Important Notes

  • Never draw blood or take blood pressure in the arm with an AV fistula.
  • Hyperkalemia + peaked T waves in CKD patient = cardiac monitoring and immediate treatment.

Clinical Tips

  • Renal diet memory: "Keep it LOW" โ€” Low K+, Low PO4, Low Na+, Low fluids.

Summary

CKD is a progressive, systemic disease requiring careful management of fluid, electrolytes, and comorbidities. Nursing focuses on slowing progression and managing complications.

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